The present study describe about selection of diluents to formulate successful tablet of glimepiride. Glimepiride is chosen as drug for which dissolution minima is prescribed in literature. In the present study three diluents are studied either alone or in combination to formulate tablet dosage form. All other ingredients are used commonly in present study and thus eight formulations are prepared. While granulating in some formulations, organic solvent dichloromethane or combination of dichloromethane and isopropylalcohol (1:1) are used, thus alteration in diluents (s) or organic solvents used in method are made. Deliberately name of diluent(s), intragranular disintegrant, binder, extragranular disintegrant, lubricant, glidant and colour are not given in present study. All ingredients are very commonly used in tablet formulation as well as they are economically viable. In two formulations where all ingredients are same as well as they are almost similar in evaluations, one of them only differ in using dichloromethane for dispersion of drug. The method, where dichloromethane was used, was discarded on the basis of economy and ecofriendly alternative. Present study is highly illustrative for selection of diluent (s) and method for manufacture of tablet as dosage form. The successful tablet formulation was compared with two marketed product and found superior. The successful formulated tablets were packed in PVC aluminium blister pack and subjected to stability study at 40°C2°C/75% +5% RH and 25 2C/60% + 5% RH for 2 months. Results showed that product in stable.
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